Lithium Hydroxide → (S)-2-(6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-4-methylpentanoic acid

HRID 927763노트

반응식

HRID 927763 반응식
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([NH:14][C@@H:15]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:16]([O:18]CC)=[O:17])=[O:13])[CH:9]=[CH:8][C:7]=2[N:25]2[CH2:28][C:27]([F:30])([F:29])[CH2:26]2)[CH2:3][CH2:2]1.[OH-].[Li+]>>[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([NH:14][C@@H:15]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:16]([OH:18])=[O:17])=[O:13])[CH:9]=[CH:8][C:7]=2[N:25]2[CH2:28][C:27]([F:29])([F:30])[CH2:26]2)[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 3939Lithium HydroxideHCID 71105697(S)-Ethyl 2-(6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-4-methylpentanoate

생성물 1

HCID 71087342(S)-2-(6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-4-methylpentanoic acid

실험 절차

In analogy to the procedure described in Example 5 c), (S)-ethyl 2-(6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-4-methylpentanoate was saponified with lithium hydroxide to obtain the title compound. MS (EI): m/e=396.3 [M−H]−.

출처 및 근거

ORD 기록
ord-2344c010b2574a3ba58d00c288719180
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290451B2

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