Ethyl 2-amino-2-ethylbutanoate hydrochloride → Ethyl 2-(6-(cyclopropylmethoxy)-5-(trifluoromethyl)picolinamido)-2-ethylbutanoate

HRID 927764Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 927764
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[C:15]([F:18])([F:17])[F:16])[CH2:3][CH2:2]1.Cl.[NH2:20][C:21]([CH2:29][CH3:30])([CH2:27][CH3:28])[C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[CH2:25]([O:24][C:22](=[O:23])[C:21]([NH:20][C:12]([C:10]1[CH:9]=[CH:8][C:7]([C:15]([F:18])([F:17])[F:16])=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])([CH2:29][CH3:30])[CH2:27][CH3:28])[CH3:26]

Komponenten

3

Edukt 2

HCID 24201639Ethyl 2-amino-2-ethylbutanoate hydrochlorideHCID 710874576-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid

Produkt 1

HCID 71087413Ethyl 2-(6-(cyclopropylmethoxy)-5-(trifluoromethyl)picolinamido)-2-ethylbutanoate

Versuchsvorschrift

In analogy to the procedure described in Example 293, 6-cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (Example 113 d) and ethyl 2-amino-2-ethylbutanoate hydrochloride (CAN 1135219-29-2) were condensed to the title product. MS (EI): m/e=403.4 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-aaf3a14b277341eaba5f453a92bdd830
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09290451B2

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