Dichloromethane → N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Reaction equation
[CH3:8][C:9]([CH3:10])([O:11][C:12]([N:14]([C:13]([O:56][C:57]([CH3:58])([CH3:59])[CH3:60])=[O:61])[c:15]1[n:16][cH:17][cH:18][c:19]([O:27][c:28]2[cH:29][c:30]([F:55])[c:31]([NH:35][C:36](=[O:37])[c:38]3[c:39](=[O:54])[n:40](-[c:47]4[cH:48][cH:49][c:50]([F:53])[cH:51][cH:52]4)[cH:41][cH:42][c:43]3[O:44][CH2:45][CH3:46])[cH:32][c:33]2[F:34])[c:20]1-[c:21]1[cH:22][n:23][n:24]([CH3:26])[cH:25]1)=[O:62])[CH3:63].[Cl:64][CH2:65][Cl:66].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[NH2:14][c:15]1[n:16][cH:17][cH:18][c:19]([O:27][c:28]2[cH:29][c:30]([F:55])[c:31]([NH:35][C:36](=[O:37])[c:38]3[c:39](=[O:54])[n:40](-[c:47]4[cH:48][cH:49][c:50]([F:53])[cH:51][cH:52]4)[cH:41][cH:42][c:43]3[O:44][CH2:45][CH3:46])[cH:32][c:33]2[F:34])[c:20]1-[c:21]1[cH:22][n:23][n:24]([CH3:26])[cH:25]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-0e3687b2caeb4c1ba76934269df70825
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
Loading…