Methyl 7-pivalamido-2H-chromene-8-carboxylate → Methyl 4-methyl-7-(tert-butoxycarbonylamino)-2H-chromene-8-carboxylate

HRID 927940Notes

Reaction equation

HRID 927940 reaction equation
CC(C)(C)C(NC1C(C(OC)=O)=C2C(C=CCO2)=CC=1)=O.C(OC([N:29]([C:45]([O:47][C:48]([CH3:51])([CH3:50])[CH3:49])=[O:46])[C:30]1[CH:39]=[CH:38][CH:37]=[C:36]([O:40][CH2:41][C:42]#[C:43][CH3:44])[C:31]=1[C:32]([O:34][CH3:35])=[O:33])=O)(C)(C)C>>[CH3:44][C:43]1[C:37]2[C:36](=[C:31]([C:32]([O:34][CH3:35])=[O:33])[C:30]([NH:29][C:45]([O:47][C:48]([CH3:51])([CH3:49])[CH3:50])=[O:46])=[CH:39][CH:38]=2)[O:40][CH2:41][CH:42]=1

Participants

3

Reactant 2

HCID 70983794Methyl 7-pivalamido-2H-chromene-8-carboxylateHCID 90086596Methyl 2-[bis-(tert-butyoxycarbonyl)amino]-6-(but-2-ynyloxy)benzoate2×

Product 1

HCID 71006962Methyl 4-methyl-7-(tert-butoxycarbonylamino)-2H-chromene-8-carboxylate

Procedure

Prepared by proceeding in a similar manner to Intermediate 45, starting from methyl 2-[bis-(tert-butyoxycarbonyl)amino]-6-(but-2-ynyloxy)benzoate (Intermediate 54).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-203d07f96e88422faa842656aedde758
Source dataset
uspto-grants-2016_03
Patent number
US09290472B2

Reaction notes

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