反应详情

A solution of 4-dimethylaminobutylamine (3.0 g) in ethyl formate (30 mL) was stirred and heated at reflux under an atmosphere of nitrogen for 3 hours. After cooling, the mixture was evaporated to dryness and the residue was purified by chromatography on silica, eluting with a mixture of methanol and DCM (20%) to give N-(4-dimethylaminobutyl)formamide (2.7 g) as a pale yellow oil.

1. temperatureheated
2. temperatureat reflux under an atmosphere of nitrogen for 3 hours
3. temperatureAfter cooling
4. customthe mixture was evaporated to dryness
5. customthe residue was purified by chromatography on silica
6. washeluting with a mixture of methanol and DCM (20%)