反应详情

温度

0 °C

((S)-1-Acetylpyrrolidin-2-yl)acetonitrile (Intermediate 137, 1.0 g) was added portionwise to a stirred, cooled solution of lithium aluminium hydride (0.36 g) in THF (30 mL) under an atmosphere of nitrogen while maintaining the temperature at 0° C. The mixture was allowed to warm to room temperature then heated at reflux for 2 hours. After cooling, ethanol (4 mL) was added dropwise and the resultant solid was filtered off. The filtrate was evaporated to dryness to give 2((S)-1-ethylpyrrolidin-2-yl)ethylamine (0.6 g) as a colourless oil.

1. temperatureto warm to room temperature
2. temperaturethen heated
3. temperatureat reflux for 2 hours
4. temperatureAfter cooling
5. filtrationthe resultant solid was filtered off
6. customThe filtrate was evaporated to dryness