tert-butyl (2R)-2-(cyanomethyl)pyrrolidine-1-carboxylate → (R)-2-(Pyrrolidin-2-yl)acetonitrile hydrochloride

HRID 928018Notes

Reaction equation

HRID 928018 reaction equation
[ClH:1].[NH:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][C:8]#[N:9].C(C[C@H]1CCCN1C(OC(C)(C)C)=O)#N>>[ClH:1].[NH:2]1[CH2:6][CH2:5][CH2:4][C@@H:3]1[CH2:7][C:8]#[N:9]

Participants

3

Reactant 2

HCID 10727173tert-butyl (2R)-2-(cyanomethyl)pyrrolidine-1-carboxylate2×HCID 86713338(S)-2-(Pyrrolidin-2-yl)acetonitrile hydrochloride

Product 1

HCID 86713341(R)-2-(Pyrrolidin-2-yl)acetonitrile hydrochloride

Procedure

Prepared by proceeding in a similar manner to Intermediate 138, starting from tert-butyl (R)-2-cyanomethylpyrrolidine-1-carboxylate (Intermediate 144) and used without further characterisation.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ba1b5a73778c47a1b85026918b8ff7f3
Source dataset
uspto-grants-2016_03
Patent number
US09290472B2

Reaction notes

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