HCID 70984611, compound → HCID 42579940, compound

HRID 928038Notes

Reaction equation

HRID 928038 reaction equation
[CH2:1]([N:3]1[CH2:7][CH2:6][C@@H:5]([CH2:8][NH:9]C(=O)OCC2C=CC=CC=2)[CH2:4]1)[CH3:2]>[Pd].CO>[CH2:1]([N:3]1[CH2:7][CH2:6][C@@H:5]([CH2:8][NH2:9])[CH2:4]1)[CH3:2]

Participants

4

Reactant 1

HCID 70984611HCID 70984611, compound2×

Product 1

HCID 42579940HCID 42579940, compoundYield 90.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Palladium on carbon (10%, 0.3 g) was added to a solution of benzyl N—((S)-1-ethylpyrrolidin-3-ylmethyl)carbamate (Intermediate 170, 1.8 g) in methanol (20 mL) and the resultant mixture was stirred under an atmosphere of hydrogen for 24 hours. The mixture was filtered and the filtrate was evaporated to dryness to give ((S)-1-ethylpyrrolidin-3-yl)methylamine (0.8 g) as a colourless oil, which was used without further characterisation.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-008ab6cc2d0440e796ea65c8ebe2bfac
Source dataset
uspto-grants-2016_03
Patent number
US09290472B2

Reaction notes

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