tert-butyl (S)-3-(2-chlorosulfonyl-5-fluorobenzyloxy)pyrrolidine-1-carboxylate → tert-butyl (R)-3-(2-chlorosulfonyl-5-fluorobenzyloxy)pyrrolidine-1-carboxylate

HRID 928073Notes

Reaction equation

HRID 928073 reaction equation
[Cl:1][S:2]([C:5]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:6]=1[CH2:7][O:8][C@H:9]1[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10]1)(=[O:4])=[O:3].BrC1C=CC(F)=CC=1CO[C@@H]1CCN(C(OC(C)(C)C)=O)C1>>[Cl:1][S:2]([C:5]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:6]=1[CH2:7][O:8][C@@H:9]1[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:19])([CH3:20])[CH3:18])=[O:15])[CH2:10]1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 86713368tert-butyl (S)-3-(2-chlorosulfonyl-5-fluorobenzyloxy)pyrrolidine-1-carboxylateHCID 86713373tert-butyl (R)-3-(2-bromo-5-fluorobenzyloxy)pyrrolidine-1-carboxylate2×

Product 1

HCID 86713372tert-butyl (R)-3-(2-chlorosulfonyl-5-fluorobenzyloxy)pyrrolidine-1-carboxylate

Procedure

Prepared by proceeding in a similar manner to Intermediate 215, starting from tert-butyl (R)-3-(2-bromo-5-fluorobenzyloxy)pyrrolidine-1-carboxylate (Intermediate 220).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a6341dde41574808bf994451aef537cf
Source dataset
uspto-grants-2016_03
Patent number
US09290472B2

Reaction notes

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