Thionyl Chloride → HCID 178511254, compound
Reaction equation
[C:1]([C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([OH:11])=O)[CH2:5][CH2:4]1)#[N:2].S(Cl)([Cl:14])=O>ClCCl>[C:1]([C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([Cl:14])=[O:11])[CH2:5][CH2:4]1)#[N:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 38 °C
Procedure
To a solution of trans-4-cyanocyclohexanecarboxylic acid (1.29 g, 8.42 mmol) in dichloromethane (7.7 mL) was added thionyl chloride (2.0 M in dichloromethane, 10.11 mL, 20.21 mmol) and the reaction was heated at 38° C. overnight. Then, the reaction was concentrated to afford trans-4-cyanocyclohexanecarbonyl chloride that was used in the next step without further purification.
Workup
- concentrationThen, the reaction was concentrated
Sources & evidence
- ORD record
- ord-8d1fe40233724cbcacf666983f0a570e
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09290490B2
Reaction notes
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