Thionyl Chloride → HCID 178511254, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of trans-4-cyanocyclohexanecarboxylic acid (1.29 g, 8.42 mmol) in dichloromethane (7.7 mL) was added thionyl chloride (2.0 M in dichloromethane, 10.11 mL, 20.21 mmol) and the reaction was heated at 38° C. overnight. Then, the reaction was concentrated to afford trans-4-cyanocyclohexanecarbonyl chloride that was used in the next step without further purification.

Provenance & Evidence