反应详情

Ethyl trans-4-{2-fluoro-1-hydroxy-1-[5-(3-methyl-5-{[4-(trifluoromethyl)-pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]ethyl}cyclohexanecarboxylate (72 mg, 0.130 mmol) was dissolved in HCl (10 M in water, 2 ml, 20.0 mmol) and heated to reflux for 20 min. The reaction was diluted with DMSO and purified on reverse phase HPLC (acetonitrile/water with a 0.1% TFA modifier) to afford racemic trans-4-{2-fluoro-1-hydroxy-1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]ethyl}cyclohexanecarboxylic acid. MS ESI calc'd. for C24H24F4N4O3S [M+H]+ 525. found 525.

1. temperatureheated
2. temperatureto reflux for 20 min
3. custompurified on reverse phase HPLC (acetonitrile/water with a 0.1% TFA modifier)