Trifluoroacetic acid → 9-isopropyl-N-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-3-yl)-9H-purin-6-amine

HRID 928172Notes

Reaction equation

HRID 928172 reaction equation
[CH:1]([N:4]1[CH:12]=[N:11][C:10]2[C:5]1=[N:6][C:7]([CH:20]1[CH2:25][CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]1)=[N:8][C:9]=2[NH:13][C:14]1[CH:15]=[N:16][N:17]([CH3:19])[CH:18]=1)([CH3:3])[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:1]([N:4]1[CH:12]=[N:11][C:10]2[C:5]1=[N:6][C:7]([CH:20]1[CH2:25][CH2:24][CH2:23][NH:22][CH2:21]1)=[N:8][C:9]=2[NH:13][C:14]1[CH:15]=[N:16][N:17]([CH3:19])[CH:18]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118073533tert-butyl 3-(9-isopropyl-6-((1-methyl-1H-pyrazol-4-yl)amino)-9H-purin-2-yl)piperidine-1-carboxylate

Product 1

HCID 1180737239-isopropyl-N-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-3-yl)-9H-purin-6-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 3-(9-isopropyl-6-((1-methyl-1H-pyrazol-4-yl)amino)-9H-purin-2-yl)piperidine-1-carboxylate (620 mg) in DCM (15 mL) was added TFA (1.2 mL). The resulting solution was stirred at ambient temperature for 1 hr. The volatiles were removed to give the crude title compound that was used in the next step without further purification.

Workup

  1. customThe volatiles were removed

Sources & evidence

ORD record
ord-fe6aacb6893640e7b7ee5f9e54e5f168
Source dataset
uspto-grants-2016_03
Patent number
US09290496B2

Reaction notes

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