反应详情

A solution of 4-chloropyridine (2.0 g, 17.6 mmol), 50% butylamine in water (30 mL) was heated at 150° C. in a sealed tube for 24 h. The reaction mixture was evaporated, partitioned between 0.1 N NaOH and CH2Cl2, dried (Na2SO4) and evaporated. Crystallization in ether/petroleum ether 4:1 afforded 2.4 g of the title product 113 as a white powder (LCMS analysis).

1. customThe reaction mixture was evaporated
2. custompartitioned between 0.1 N NaOH and CH2Cl2
3. dry with materialdried (Na2SO4)
4. customevaporated
5. customCrystallization in ether/petroleum ether 4:1