Benzenamine, 4-(4-morpholinyl)- → HCID 57742380, compound

HRID 928282Notes

Reaction equation

HRID 928282 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:8]2[NH:17][C:16](=O)[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1.[CH2:20]1[N:25]([C:26]2[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=2)[CH2:24][CH2:23][O:22][CH2:21]1.C(N(C1C=CN=CC=1)C1C2C(=NC=CN=2)N=C(C2C=C(Br)C=CC=2F)N=1)CCC>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:8]2[N:17]=[C:16]([NH:32][C:29]3[CH:28]=[CH:27][C:26]([N:25]4[CH2:20][CH2:21][O:22][CH2:23][CH2:24]4)=[CH:31][CH:30]=3)[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 444320664-[(Butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridineHCID 1361099582-(5-Bromo-2-fluoro-phenyl)-3H-pteridin-4-one

Product 1

HCID 57742380HCID 57742380, compound

Procedure

The title product was synthesized by reaction of the 2-(5-bromo-2-fluorophenyl)-pteridin-4-one 104 with 4-(4-morpholino)aniline following the procedure described for 4-[(butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridine 3.

Sources & evidence

ORD record
ord-06ad39e80f4d4d6d8cfc7956e90f851c
Source dataset
uspto-grants-2016_03
Patent number
US09290502B2

Reaction notes

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