4-Aminopyridine → HCID 11428611, compound

HRID 928291Notes

Reaction equation

HRID 928291 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([C:9]2[NH:18][C:17](=O)[C:16]3[C:11](=[N:12][CH:13]=[CH:14][N:15]=3)[N:10]=2)[CH:6]=[CH:7][CH:8]=1.[NH2:22][C:23]1[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=1.C(N(C1C=CN=CC=1)C1C2C(=NC=CN=2)N=C(C2C=C(Br)C=CC=2F)N=1)CCC>>[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([C:9]2[N:18]=[C:17]([NH:22][C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)[C:16]3[C:11](=[N:12][CH:13]=[CH:14][N:15]=3)[N:10]=2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 17274-AminopyridineHCID 444320664-[(Butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridineHCID 136346329HCID 136346329, compound

Product 1

HCID 11428611HCID 11428611, compound

Procedure

The title product was synthesized by reaction of the 2-(3-trifluoromethylphenyl)-pteridin-4-one with 4-aminopyridine following the procedure described for 4-[(butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridine 3.

Sources & evidence

ORD record
ord-8ae59e26d7c347b69bc9db9ff298c375
Source dataset
uspto-grants-2016_03
Patent number
US09290502B2

Reaction notes

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