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HRID928303

反应详情

EQUATION

反应方程式

HRID 928303 的结构方程式

REACTANTS

反应物

1
结构：Nc1nccn2c([C@@H]3CCCN3)nc(-c3ccc(C(=O)Nc4ccccn4)cc3)c12
HCID71226368

未命名化合物

PRODUCTS

生成物

1
结构：CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(C(=O)Nc3ccccn3)cc2)c2c(N)nccn12
HCID71226662

Acalabrutinib

C26H23N7O2

收率 18%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#CC(=O)O
溶剂HCID68535

2-Butynoic acid

C4H4O2

PROCEDURE

实验过程

This compound was prepared, in an analogous manner as described in Example 2, from the compound described in intermediate 2b and 2-butynoic acid, to afford the title compound (10.5 mg, 18.0%). Data: LCMS (B) Rt: 2.08 min; m/z 466.1 (M+H)+.

WORKUP

后处理

  1. customThis compound was prepared, in an analogous manner