HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → 3-Benzyl-1,2,4-oxadiazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Ethyl 3-benzyl-1,2,4-oxadiazole-5-carboxylate | HCID 21498802 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Benzyl-1,2,4-oxadiazole-5-carboxylic acid | HCID 49874514 | — |
Reaction Steps
A mixture of 3-Benzyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester (360 mg, 1.6 mmol) and lithiumhydroxide-hydrate (65 mg, 1.6 mmol) in 10 mL MeOH and 5 mL water was stirred at room temperature for 1 h. The mixture was evaporated in vacuo to yield the crude product which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290485B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-f8df3757be9f4796900ea61f8a839c0e |
| Source note | uspto-grants-2016_03 |