Lithium hydroxide, monohydrate → 3-Benzyl-1,2,4-oxadiazole-5-carboxylic acid

HRID 928363Notes

Reaction equation

HRID 928363 reaction equation
C([O:3][C:4]([C:6]1[O:10][N:9]=[C:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:7]=1)=[O:5])C.O.[OH-].[Li+]>CO.O>[CH2:11]([C:8]1[N:7]=[C:6]([C:4]([OH:5])=[O:3])[O:10][N:9]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 21498802HCID 21498802, compound

Product 1

HCID 498745143-Benzyl-1,2,4-oxadiazole-5-carboxylic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 3-Benzyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester (360 mg, 1.6 mmol) and lithiumhydroxide-hydrate (65 mg, 1.6 mmol) in 10 mL MeOH and 5 mL water was stirred at room temperature for 1 h. The mixture was evaporated in vacuo to yield the crude product which was used in the next step without further purification.

Workup

  1. customThe mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-f8df3757be9f4796900ea61f8a839c0e
Source dataset
uspto-grants-2016_03
Patent number
US09290485B2

Reaction notes

Loading…