Cyclopropylamine → HCID 66723453, compound

HRID 928408Notes

Reaction equation

HRID 928408 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([N:18]=[C:19]=[O:20])=[CH:14][CH:13]=2)[CH:10]=1)=[O:5])[CH3:2].[CH:21]1([NH2:24])[CH2:23][CH2:22]1>C1COCC1>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([NH:18][C:19]([NH:24][CH:21]3[CH2:23][CH2:22]3)=[O:20])=[CH:16][CH:17]=2)[CH:10]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 86661851HCID 86661851, compound

Product 1

HCID 66723453HCID 66723453, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
23 °C

Procedure

To a solution of 1-(4-isocyanato-benzyl)-1H-pyrazole-4-carboxylic acid ethyl ester (99 mg, 0.365 mmol) in THF (2 ml) was added cyclopropylamine (41.7 mg, 0.730 mmol). The resulting solution was stirred for 30 min at 23° C. The solvent was evaporated, and the residual white solid was triturated in diethyl ether, filtered, washed with diethyl ether and ethanol, and dried under vacuum to afford the title compound.

Workup

  1. customThe solvent was evaporated
  2. customthe residual white solid was triturated in diethyl ether
  3. filtrationfiltered
  4. washwashed with diethyl ether and ethanol
  5. customdried under vacuum

Sources & evidence

ORD record
ord-48bf0e675ef4421fa323e0d0655891f9
Source dataset
uspto-grants-2016_03
Patent number
US09290485B2

Reaction notes

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