Trifluoroacetic acid → HCID 58081333, compound

HRID 928441Notes

Reaction equation

HRID 928441 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH2:12][N:13]3[CH:17]=[C:16]([C:18]([NH:20][CH2:21][C:22]4[C:23]([CH3:37])=[CH:24][C:25]([NH:29]C(=O)OC(C)(C)C)=[N:26][C:27]=4[CH3:28])=[O:19])[N:15]=[N:14]3)=[N:9]2)=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:29][C:25]1[N:26]=[C:27]([CH3:28])[C:22]([CH2:21][NH:20][C:18]([C:16]2[N:15]=[N:14][N:13]([CH2:12][C:8]3[CH:7]=[CH:6][C:5]4[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=4)[N:9]=3)[CH:17]=2)=[O:19])=[C:23]([CH3:37])[CH:24]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58081332HCID 58081332, compound

Product 1

HCID 58081333HCID 58081333, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
23 °C

Procedure

To a solution of tert-butyl (5-((1-((7-chloroquinolin-2-yl)methyl)-1H-1,2,3-triazole-4-carboxamido)methyl)-4,6-dimethylpyridin-2-yl)carbamate (46.7 mg, 0.089 mmol) in DCM (0.6 ml) was added TFA (0.138 ml, 1.789 mmol). Reaction mixture was stirred overnight at 23° C.

Workup

  1. customReaction mixture

Sources & evidence

ORD record
ord-6d256b31de0f446091a21bf5addbcdcd
Source dataset
uspto-grants-2016_03
Patent number
US09290485B2

Reaction notes

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