反应详情

温度

40 °C

4-Piperidinemethanol (987 mg, 8.57 mmol) was added to a stirred suspension of 2,4-dichloro-5-phenyl-thieno[2,3-d]pyrimidine (2 g, 7.14 mmol) and triethylamine (2.18 ml, 15.7 mmol) in dry ethanol (ml) at room temperature. Reaction was warmed to 40° C. and the resulting solution stirred for ˜2 h. Reaction was allowed to cool to room temperature and poured onto ice/water (50 ml). The resulting suspension was filtered and the solid dried in a vacuum oven at 40° C. The desired compound was obtained as a pale yellow solid (2.4 g, 93%). LCMS: (M+1) 360, RT=4.69 min.

1. customReaction
2. customReaction
3. temperatureto cool to room temperature
4. additionpoured onto ice/water (50 ml)
5. filtrationThe resulting suspension was filtered
6. customthe solid dried in a vacuum oven at 40° C