4-Fluorobenzaldehyde → 5-(4-Fluorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

HRID 928714Notes

Reaction equation

[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.ClC1C=CC(C[CH:16]2[C:21](=[O:22])[O:20][C:19]([CH3:24])([CH3:23])[O:18][C:17]2=[O:25])=CC=1.ClC1C=CC(CC(C(O)=O)C(O)=O)=CC=1>>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][CH:16]2[C:21](=[O:22])[O:20][C:19]([CH3:24])([CH3:23])[O:18][C:17]2=[O:25])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 680234-Fluorobenzaldehyde

HCID 27851452-(4-Chlorobenzyl)malonic acid

HCID 108801105-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Product 1

HCID 860963525-(4-Fluorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Procedure

The title compound was prepared using 4-fluorobenzaldehyde in place of 4-chlorobenzaldehyde using the procedure described for the preparation of 5-(4-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 3: step a).

Sources & evidence

ORD record: ord-d4b06cda4f33488fb6d53e919145d34f
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09290476B2

Reaction notes

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