2-(4-Fluorobenzyl)malonic acid → 6-Bromo-2,4-dichloro-3-(4-fluorobenzyl)quinoline

HRID 928716Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 928716
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:12])[C:6]([CH2:13][C:14]1[CH:19]=[CH:18][C:17](Cl)=[CH:16][CH:15]=1)=[C:5]2[Cl:21].[F:22]C1C=CC(CC(C(O)=O)C(O)=O)=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:12])[C:6]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([F:22])=[CH:16][CH:15]=1)=[C:5]2[Cl:21]

Komponenten

3

Edukt 2

HCID 151206432-(4-Fluorobenzyl)malonic acid2×HCID 867155806-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline3×

Produkt 1

HCID 867155796-Bromo-2,4-dichloro-3-(4-fluorobenzyl)quinoline

Versuchsvorschrift

The title compound was prepared by substituting 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b) with 2-(4-fluorobenzyl)malonic acid (Intermediate 4: step b) then following the procedure described for the preparation of 6-bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline (Intermediate 3: step c).

Quellen und Nachweise

ORD-Eintrag
ord-1c00ccf7c7c246f4bad9327107480ace
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09290476B2

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