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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 928716Generated: October 25, 2026

2-(4-Fluorobenzyl)malonic acid → 6-Bromo-2,4-dichloro-3-(4-fluorobenzyl)quinoline

https://huagongshe.com/reaction/928716

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-Fluorobenzyl)malonic acidHCID 15120643—
Reactant6-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinolineHCID 86715580—
Product6-Bromo-2,4-dichloro-3-(4-fluorobenzyl)quinolineHCID 86715579—

Reaction Steps

The title compound was prepared by substituting 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b) with 2-(4-fluorobenzyl)malonic acid (Intermediate 4: step b) then following the procedure described for the preparation of 6-bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline (Intermediate 3: step c).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290476B2
Source datasetuspto-grants-2016_03
ORD IDord-1c00ccf7c7c246f4bad9327107480ace
Source noteuspto-grants-2016_03