5-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione → 2-(4-Methylsulfonylbenzyl)malonic acid

HRID 928727Notes

Reaction equation

HRID 928727 reaction equation
ClC1C=CC(CC2C(=O)OC(C)(C)OC2=O)=CC=1.BrC1C=C2C(=CC=1)N=C(Cl)C(CC1C=CC(Cl)=CC=1)=C2Cl.[CH3:40][S:41]([C:44]1[CH:60]=[CH:59][C:47]([CH2:48][CH:49]2[C:54](=[O:55])[O:53]C(C)(C)[O:51][C:50]2=[O:58])=[CH:46][CH:45]=1)(=[O:43])=[O:42]>>[CH3:40][S:41]([C:44]1[CH:45]=[CH:46][C:47]([CH2:48][CH:49]([C:50]([OH:58])=[O:51])[C:54]([OH:55])=[O:53])=[CH:59][CH:60]=1)(=[O:42])=[O:43]

Participants

4

Reactant 3

HCID 108801105-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 867155806-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline3×HCID 867155855-(4-Methylsulfonylbenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Product 1

HCID 867155862-(4-Methylsulfonylbenzyl)malonic acid

Procedure

The title compound was prepared by substituting 5-(4-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 3: step a) with 5-(4-methylsulfonylbenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 8: step a) then following the procedure described for the preparation of 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b).

Sources & evidence

ORD record
ord-8a1df965ac81431a80e582799c1c48fe
Source dataset
uspto-grants-2016_03
Patent number
US09290476B2

Reaction notes

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