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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 928727Generated: November 1, 2026

5-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione → 2-(4-Methylsulfonylbenzyl)malonic acid

https://huagongshe.com/reaction/928727

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 10880110—
Reactant6-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinolineHCID 86715580—
Reactant5-(4-Methylsulfonylbenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 86715585—
Product2-(4-Methylsulfonylbenzyl)malonic acidHCID 86715586—

Reaction Steps

The title compound was prepared by substituting 5-(4-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 3: step a) with 5-(4-methylsulfonylbenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 8: step a) then following the procedure described for the preparation of 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290476B2
Source datasetuspto-grants-2016_03
ORD IDord-8a1df965ac81431a80e582799c1c48fe
Source noteuspto-grants-2016_03