2-Thiophenecarboxaldehyde → 1,3-Dioxane-4,6-dione, 2,2-dimethyl-5-(2-thienylmethyl)-

HRID 928729Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=O.ClC1C=CC(C[CH:14]2[C:19](=[O:20])[O:18][C:17]([CH3:22])([CH3:21])[O:16][C:15]2=[O:23])=CC=1.BrC1C=C2C(=CC=1)N=C(Cl)C(CC1C=CC(Cl)=CC=1)=C2Cl>>[CH3:21][C:17]1([CH3:22])[O:18][C:19](=[O:20])[CH:14]([CH2:6][C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)[C:15](=[O:23])[O:16]1

Participants

Reactant 3

HCID 73642-Thiophenecarboxaldehyde

HCID 108801105-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

HCID 867155806-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline

Product 1

HCID 109556791,3-Dioxane-4,6-dione, 2,2-dimethyl-5-(2-thienylmethyl)-

Procedure

The title compound was prepared using thiophene-2-carbaldehyde in place of 4-chlorobenzaldehyde using the procedure described for the preparation of 5-(4-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 3: step a).

Sources & evidence

ORD record: ord-3639582d0c2e450aa1e2a8d649e58037
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09290476B2

Reaction notes

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