5-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione → [(Thiophen-2-yl)methyl]propanedioic acid

HRID 928730Notes

Reaction equation

HRID 928730 reaction equation
ClC1C=CC(CC2C(=O)OC(C)(C)OC2=O)=CC=1.BrC1C=C2C(=CC=1)N=C(Cl)C(CC1C=CC(Cl)=CC=1)=C2Cl.CC1(C)[O:46][C:45](=[O:47])[CH:44]([CH2:48][C:49]2[S:50][CH:51]=[CH:52][CH:53]=2)[C:43](=[O:54])[O:42]1>>[S:50]1[CH:51]=[CH:52][CH:53]=[C:49]1[CH2:48][CH:44]([C:45]([OH:47])=[O:46])[C:43]([OH:54])=[O:42]

Participants

4

Reactant 3

HCID 108801105-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 109556791,3-Dioxane-4,6-dione, 2,2-dimethyl-5-(2-thienylmethyl)-HCID 867155806-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline3×

Product 1

HCID 236591[(Thiophen-2-yl)methyl]propanedioic acid

Procedure

The title compound was prepared by substituting 5-(4-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 3: step a) with 2,2-dimethyl-5-(thiophen-2-ylmethyl)-1,3-dioxane-4,6-dione (Intermediate 9: step a) then following the procedure described for the preparation of 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b).

Sources & evidence

ORD record
ord-1c6103d54bde46319a4dfb19bf1980a9
Source dataset
uspto-grants-2016_03
Patent number
US09290476B2

Reaction notes

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