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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 928730Generated: November 1, 2026

5-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione → [(Thiophen-2-yl)methyl]propanedioic acid

https://huagongshe.com/reaction/928730

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 10880110—
Reactant1,3-Dioxane-4,6-dione, 2,2-dimethyl-5-(2-thienylmethyl)-HCID 10955679—
Reactant6-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinolineHCID 86715580—
Product[(Thiophen-2-yl)methyl]propanedioic acidHCID 236591—

Reaction Steps

The title compound was prepared by substituting 5-(4-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 3: step a) with 2,2-dimethyl-5-(thiophen-2-ylmethyl)-1,3-dioxane-4,6-dione (Intermediate 9: step a) then following the procedure described for the preparation of 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290476B2
Source datasetuspto-grants-2016_03
ORD IDord-1c6103d54bde46319a4dfb19bf1980a9
Source noteuspto-grants-2016_03