[(Thiophen-2-yl)methyl]propanedioic acid → HCID 86715588, compound

HRID 928731Notes

Reaction equation

HRID 928731 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:12])[C:6]([CH2:13][C:14]1C=C[C:17](Cl)=[CH:16][CH:15]=1)=[C:5]2[Cl:21].[S:22]1C=CC=C1CC(C(O)=O)C(O)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:12])[C:6]([CH2:13][C:14]1[S:22][CH:17]=[CH:16][CH:15]=1)=[C:5]2[Cl:21]

Participants

3

Reactant 2

HCID 236591[(Thiophen-2-yl)methyl]propanedioic acid2×HCID 867155806-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline3×

Product 1

HCID 86715588HCID 86715588, compound

Procedure

The title compound was prepared by substituting 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b) with 2-(thiophen-2-ylmethyl)malonic acid (Intermediate 9: step b) then following the procedure described for the preparation of 6-bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline (Intermediate 3: step c).

Sources & evidence

ORD record
ord-f5b8694512814168a5a802e982ada1ed
Source dataset
uspto-grants-2016_03
Patent number
US09290476B2

Reaction notes

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