1-Benzothiophene-2-carbaldehyde → 5-(Benzo[b]thiophen-2-ylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

HRID 928732Notes

Reaction equation

HRID 928732 reaction equation
[S:1]1[C:5]([CH:6]=O)=[CH:4][C:3]2[CH:8]=[CH:9][CH:10]=[CH:11][C:2]1=2.ClC1C=CC(C[CH:18]2[C:23](=[O:24])[O:22][C:21]([CH3:26])([CH3:25])[O:20][C:19]2=[O:27])=CC=1.BrC1C=C2C(=CC=1)N=C(Cl)C(CC1C=CC(Cl)=CC=1)=C2Cl>>[S:1]1[C:5]([CH2:6][CH:18]2[C:23](=[O:24])[O:22][C:21]([CH3:26])([CH3:25])[O:20][C:19]2=[O:27])=[CH:4][C:3]2[CH:8]=[CH:9][CH:10]=[CH:11][C:2]1=2

Participants

4

Reactant 3

HCID 7365001-Benzothiophene-2-carbaldehydeHCID 108801105-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 867155806-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline

Product 1

HCID 867155895-(Benzo[b]thiophen-2-ylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Procedure

The title compound was prepared using benzo[b]thiophene-2-carbaldehyde in place of 4-chlorobenzaldehyde using the procedure described for the preparation of 5-(4-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 3: step a).

Sources & evidence

ORD record
ord-1a54147a11a740f597ad00f10da1feba
Source dataset
uspto-grants-2016_03
Patent number
US09290476B2

Reaction notes

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