5-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione → 2-(Benzo[b]thiophen-2-ylmethyl)malonic acid

HRID 928733Notes

Reaction equation

HRID 928733 reaction equation
ClC1C=CC(CC2C(=O)OC(C)(C)OC2=O)=CC=1.BrC1C=C2C(=CC=1)N=C(Cl)C(CC1C=CC(Cl)=CC=1)=C2Cl.[S:40]1[C:44]([CH2:45][CH:46]2[C:51](=[O:52])[O:50]C(C)(C)[O:48][C:47]2=[O:55])=[CH:43][C:42]2[CH:56]=[CH:57][CH:58]=[CH:59][C:41]1=2>>[S:40]1[C:44]([CH2:45][CH:46]([C:51]([OH:52])=[O:50])[C:47]([OH:55])=[O:48])=[CH:43][C:42]2[CH:56]=[CH:57][CH:58]=[CH:59][C:41]1=2

Participants

4

Reactant 3

HCID 108801105-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 867155806-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline3×HCID 867155895-(Benzo[b]thiophen-2-ylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Product 1

HCID 867155902-(Benzo[b]thiophen-2-ylmethyl)malonic acid

Procedure

The title compound was prepared by substituting 5-(4-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 3: step a) with 5-(benzo[b]thiophen-2-ylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 10: step a) then following the procedure described for the preparation of 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b).

Sources & evidence

ORD record
ord-5c4fd798f1e8481cb304e201827a6a97
Source dataset
uspto-grants-2016_03
Patent number
US09290476B2

Reaction notes

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