HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione → 2-(Benzo[b]thiophen-2-ylmethyl)malonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 10880110 | — |
| Reactant | 6-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline | HCID 86715580 | — |
| Reactant | 5-(Benzo[b]thiophen-2-ylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 86715589 | — |
| Product | 2-(Benzo[b]thiophen-2-ylmethyl)malonic acid | HCID 86715590 | — |
Reaction Steps
The title compound was prepared by substituting 5-(4-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 3: step a) with 5-(benzo[b]thiophen-2-ylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 10: step a) then following the procedure described for the preparation of 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290476B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-5c4fd798f1e8481cb304e201827a6a97 |
| Source note | uspto-grants-2016_03 |