3-Pyridinecarboxaldehyde → (4-fluorophenyl)(1-methyl-1H-imidazol-5-yl)methanol

HRID 928759Notes

Reaction equation

HRID 928759 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([Mg]Br)=[CH:4][CH:3]=1.[CH3:10][N:11]1[C:15]([CH:16]=[O:17])=[CH:14][N:13]=[CH:12]1.C(=O)C1C=CC=NC=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:16]([C:15]2[N:11]([CH3:10])[CH:12]=[N:13][CH:14]=2)[OH:17])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 103713-PyridinecarboxaldehydeHCID 5735921-methyl-1H-imidazole-5-carbaldehydeHCID 178418676HCID 178418676, compound

Product 1

HCID 66117559(4-fluorophenyl)(1-methyl-1H-imidazol-5-yl)methanol

Procedure

The title compound was prepared analogously to the method in Intermediate 27: step a using (4-fluorophenyl)magnesium bromide and 1-methyl-1H-imidazole-5-carbaldehyde in place of (3,4-dimethoxyphenyl)magnesium bromide and nicotinaldehyde, respectively.

Sources & evidence

ORD record
ord-9aadebd50e8d49c685350361aaae2eaf
Source dataset
uspto-grants-2016_03
Patent number
US09290476B2

Reaction notes

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