反应详情

温度

50 °C

Sodium carbonate (19.50 g, 183.96 mmol) was dispersed into a solution of 2,3,4-trifluorophenol (13.64 g, 92.10 mmol) in acetone (300 mL). To the stirred suspension was added benzyl bromide (17.31 g, 101.21 mmol) dropwisely. The mixture was heated under reflux at 50° C. for 24 h. The acetone was removed under reduced pressure and the residue was dissolved in water (300 mL). The solution was extracted with ethyl acetate (100 mL×2). The combined organic extracts were washed with 5% sodium hydroxide (100 mL) and brine (100 mL) sequentially and dried over Na2SO4. The solvent was removed in vacuo to yield a pale yellow solid (19.89 g, 90.7% yield). 1H NMR (400 MHz, CDCl3): δ 7.40 (m, 5H), 6.85 (m, 1H), 6.64 (m, 1H), 5.15 (s, 2H).

1. temperatureThe mixture was heated
2. customThe acetone was removed under reduced pressure
3. dissolutionthe residue was dissolved in water (300 mL)
4. extractionThe solution was extracted with ethyl acetate (100 mL×2)
5. washThe combined organic extracts were washed with 5% sodium hydroxide (100 mL) and brine (100 mL) sequentially
6. dry with materialdried over Na2SO4
7. customThe solvent was removed in vacuo