1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 118022995, compound

Participants

Reaction Steps

In an appropriate reaction vessel, to N-(3-chloro-1-(pyridin-3-yl)-1H -pyrazol-4-yl)-N-ethylpiperidine-4-carboxamide may be added 3,3,3-trifluoropropanoic acid (about 1.0 to about 2.0 eq), DMAP (about 2.0 to about 3.0 eq), and EDCI (about 1.5 to about 3.0 eq) in a solvent, such as CH2Cl2 (at a concentration between about 0.01 M to about 1 M). The reaction may be stirred at a temperature from about 0° C. to about 50° C. until determined to be completed. After completion of the reaction, the product may be obtained using standard organic chemistry techniques for workup and purification.

Provenance & Evidence