1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 118022995, compound

HRID 929312Notes

Reaction equation

HRID 929312 reaction equation
[Cl:1][C:2]1[C:6]([N:7]([CH2:16][CH3:17])[C:8]([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])=[CH:5][N:4]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[N:3]=1.[F:24][C:25]([F:31])([F:30])[CH2:26][C:27](O)=[O:28].CCN=C=NCCCN(C)C>CN(C1C=CN=CC=1)C>[Cl:1][C:2]1[C:6]([N:7]([CH2:16][CH3:17])[C:8]([CH:10]2[CH2:15][CH2:14][N:13]([C:27](=[O:28])[CH2:26][C:25]([F:31])([F:30])[F:24])[CH2:12][CH2:11]2)=[O:9])=[CH:5][N:4]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[N:3]=1

Participants

5

Reactant 3

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 27779723,3,3-Trifluoropropionic acidHCID 118023946HCID 118023946, compound

Product 1

HCID 118022995HCID 118022995, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

In an appropriate reaction vessel, to N-(3-chloro-1-(pyridin-3-yl)-1H -pyrazol-4-yl)-N-ethylpiperidine-4-carboxamide may be added 3,3,3-trifluoropropanoic acid (about 1.0 to about 2.0 eq), DMAP (about 2.0 to about 3.0 eq), and EDCI (about 1.5 to about 3.0 eq) in a solvent, such as CH2Cl2 (at a concentration between about 0.01 M to about 1 M). The reaction may be stirred at a temperature from about 0° C. to about 50° C. until determined to be completed. After completion of the reaction, the product may be obtained using standard organic chemistry techniques for workup and purification.

Workup

  1. concentrationsuch as CH2Cl2 (at a concentration between about 0.01 M to about 1 M)
  2. customThe reaction
  3. customAfter completion of the reaction
  4. customthe product may be obtained
  5. customfor workup and purification

Sources & evidence

ORD record
ord-af911e4de4af4e00aa41bb63b7dbd7f5
Source dataset
uspto-grants-2016_03
Patent number
US09295260B2

Reaction notes

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