Tetrahydrofuran → 4-[2-(1-Hydroxy-1-methylethyl)phenyl]-1-methylpiperidin-4-ol
Reaction equation
[Br:1][c:2]1[c:3]([C:8]([CH3:9])([CH3:10])[OH:11])[cH:4][cH:5][cH:6][cH:7]1.[CH3:17][N:18]1[CH2:19][CH2:20][C:21](=[O:24])[CH2:22][CH2:23]1.[Li:12][CH2:13][CH2:14][CH2:15][CH3:16].[O:25]1[CH2:26][CH2:27][CH2:28][CH2:29]1>>[c:2]1([C:21]2([OH:24])[CH2:20][CH2:19][N:18]([CH3:17])[CH2:23][CH2:22]2)[c:3]([C:8]([CH3:9])([CH3:10])[OH:11])[cH:4][cH:5][cH:6][cH:7]1Participants
5
Sources & evidence
- ORD record
- ord-55a6bf418d5c4f4c9c2e159f086415db
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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