Potassium Carbonate → HCID 86699667, compound

HRID 929550Notes

Reaction equation

HRID 929550 reaction equation
[CH3:1][NH:2][C:3]([C:5]1[C:14]2[C:9](=[C:10]([C@H:15]([CH3:24])[CH2:16][NH:17]C(=O)C(F)(F)F)[CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][N:6]=1)=[O:4].C([O-])([O-])=O.[K+].[K+]>CO.O>[NH2:17][CH2:16][C@H:15]([C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:9]=1[N:8]=[CH:7][N:6]=[C:5]2[C:3]([NH:2][CH3:1])=[O:4])[CH3:24]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 86699668HCID 86699668, compound

Product 1

HCID 86699667HCID 86699667, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

As shown in step 12-iii of Scheme 12, a solution of (S)—N-methyl-8-(1-(2,2,2-trifluoroacetamido)propan-2-yl)quinazoline-4-carboxamide (200 mg, 0.588 mmol), K2CO3 (406 mg, 2.94 mmol) in MeOH (10 mL) and water (0.5 mL) was heated at 60° C. for 1 hour. The reaction mixture concentrated under reduced pressure and dried under high vacuum to provide (S)-8-(1-aminopropan-2-yl)-N-methylquinazoline-4-carboxamide (compound 2054). LC-MS: 245.09 (M+), which was used in the following reaction as is.

Workup

  1. concentrationThe reaction mixture concentrated under reduced pressure
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-687a2ff2cc4e47d897dc6f74b012b934
Source dataset
uspto-grants-2016_03
Patent number
US09296701B2

Reaction notes

Loading…