Exo-2-bornanamine → 3-((Bicyclo[2.2.1]heptan-2-ylamino)methyl)-5-(tert-butyl)-4'-(trifluoromethoxy)-[1,1'-biphenyl]-2-ol
Reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:23]=O)[C:8]([OH:22])=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:25]1[CH:29]2[CH2:30][CH:31]([NH2:32])[CH:27]([CH2:28]2)[CH2:26]1>>[CH:27]12[CH2:28][CH:29]([CH2:25][CH2:26]1)[CH2:30][CH:31]2[NH:32][CH2:23][C:7]1[CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:19])[F:20])=[CH:13][CH:12]=2)[C:8]=1[OH:22]Participants
3
Procedure
3-((Bicyclo[2.2.1]heptan-2-ylamino)methyl)-5-(tert-butyl)-4′-(trifluoromethoxy)-[1,1′-biphenyl]-2-ol was prepared as a white solid using the procedure described in Example 5 from 5-(tert-butyl)-2-hydroxy-4′-(trifluoromethoxy)-[1,1′-biphenyl]-3-carbaldehyde (Intermediate 5) and exo-2-aminonorbornane.
Sources & evidence
- ORD record
- ord-98c31957bff545ff9b160401cbb9b7aa
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09296696B2
Reaction notes
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