HuagongsheHuagongshe Chemistry Print Report · For research reference only
Exo-2-bornanamine → 3-((Bicyclo[2.2.1]heptan-2-ylamino)methyl)-5-(tert-butyl)-4'-(trifluoromethoxy)-[1,1'-biphenyl]-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Exo-2-bornanamine | HCID 98480 | — |
| Reactant | 5-(Tert-butyl)-2-hydroxy-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbaldehyde | HCID 86718719 | — |
| Product | 3-((Bicyclo[2.2.1]heptan-2-ylamino)methyl)-5-(tert-butyl)-4'-(trifluoromethoxy)-[1,1'-biphenyl]-2-ol | HCID 90123261 | — |
Reaction Steps
3-((Bicyclo[2.2.1]heptan-2-ylamino)methyl)-5-(tert-butyl)-4′-(trifluoromethoxy)-[1,1′-biphenyl]-2-ol was prepared as a white solid using the procedure described in Example 5 from 5-(tert-butyl)-2-hydroxy-4′-(trifluoromethoxy)-[1,1′-biphenyl]-3-carbaldehyde (Intermediate 5) and exo-2-aminonorbornane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296696B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-98c31957bff545ff9b160401cbb9b7aa |
| Source note | uspto-grants-2016_03 |