Tert-Butylamine → 5-(tert-Butyl)-3-((tert-butylamino)methyl)-2',4'-dichloro-[1,1'-biphenyl]-2-ol hydrochloride

HRID 929563Notes

Reaction equation

HRID 929563 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:20]=O)[C:8]([OH:19])=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[C:22]([NH2:26])([CH3:25])([CH3:24])[CH3:23]>>[ClH:17].[C:1]([C:5]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])[C:8]([OH:19])=[C:7]([CH2:20][NH:26][C:22]([CH3:25])([CH3:24])[CH3:23])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 6385Tert-ButylamineHCID 867187245-(tert-Butyl)-2',4'-dichloro-2-hydroxy-[1,1'-biphenyl]-3-carbaldehyde

Product 1

HCID 867187255-(tert-Butyl)-3-((tert-butylamino)methyl)-2',4'-dichloro-[1,1'-biphenyl]-2-ol hydrochloride

Procedure

5-(tert-Butyl)-3-((tert-butylamino)methyl)-2′,4′-dichloro-[1,1′-biphenyl]-2-ol hydrochloride was prepared as a gray solid using the procedure described in Example 9 from 5-(tert-butyl)-2′,4′-dichloro-2-hydroxy-[1,1′-biphenyl]-3-carbaldehyde and tert-butylamine.

Sources & evidence

ORD record
ord-be303eee24a14743abc7b33278b948ab
Source dataset
uspto-grants-2016_03
Patent number
US09296696B2

Reaction notes

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