Tert-Butylamine → 5-(tert-Butyl)-3-((tert-butylamino)methyl)-2'-chloro-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ol hydrochloride

HRID 929565Notes

Reaction equation

[C:1]([C:5]1[CH:6]=[C:7]([CH:23]=O)[C:8]([OH:22])=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][C:12]=2[Cl:21])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[C:25]([NH2:29])([CH3:28])([CH3:27])[CH3:26]>>[ClH:21].[C:1]([C:5]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][C:12]=2[Cl:21])[C:8]([OH:22])=[C:7]([CH2:23][NH:29][C:25]([CH3:28])([CH3:27])[CH3:26])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 86718727HCID 86718727, compound

Product 1

HCID 867187285-(tert-Butyl)-3-((tert-butylamino)methyl)-2'-chloro-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ol hydrochloride

Procedure

5-(tert-Butyl)-3-((tert-butylamino)methyl)-2′-chloro-4′-(trifluoromethyl)-[1,1′-biphenyl]-2-ol hydrochloride was prepared as a white solid using the procedure described in Example 9 from 5-(tert-butyl)-2′-chloro-2-hydroxy-4′-(trifluoromethyl)-[1,1′-biphenyl]-3-carbaldehyde and tert-butylamine.

Sources & evidence

ORD record: ord-af384178244c4e68969154f5b70d08e4
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09296696B2

Reaction notes

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