(1-Methylcyclobutyl)amine → 5-(tert-Butyl)-3',4'-dichloro-3-(((1-methylcyclobutyl)amino)methyl)-[1,1'-biphenyl]-2-ol

HRID 929571Notes

Reaction equation

HRID 929571 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:20]=O)[C:8]([OH:19])=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([Cl:18])[CH:12]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:22][C:23]1([NH2:27])[CH2:26][CH2:25][CH2:24]1>>[C:1]([C:5]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([Cl:18])[CH:12]=2)[C:8]([OH:19])=[C:7]([CH2:20][NH:27][C:23]2([CH3:22])[CH2:26][CH2:25][CH2:24]2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 14988399(1-Methylcyclobutyl)amineHCID 867187235-(tert-Butyl)-3',4'-dichloro-2-hydroxy-[1,1'-biphenyl]-3-carbaldehyde

Product 1

HCID 752020665-(tert-Butyl)-3',4'-dichloro-3-(((1-methylcyclobutyl)amino)methyl)-[1,1'-biphenyl]-2-ol

Procedure

5-(tert-Butyl)-3′,4′-dichloro-3-(((1-methylcyclobutyl)amino)methyl)-[1,1′-biphenyl]-2-ol was prepared as a white solid using the procedure described in Example 5 from 5-(tert-butyl)-3′,4′-dichloro-2-hydroxy-[1,1′-biphenyl]-3-carbaldehyde (from Example 19, Step 1) and 1-methylcyclobutylamine.

Sources & evidence

ORD record
ord-c2d2c0d4f6094789a3244631b86d4621
Source dataset
uspto-grants-2016_03
Patent number
US09296696B2

Reaction notes

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