Tert-Butylamine → HCID 86718741, compound

HRID 929577Notes

Reaction equation

[C:1]([C:5]1[CH:6]=[C:7]([CH:22]=O)[C:8]([OH:21])=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[C:24]([NH2:28])([CH3:27])([CH3:26])[CH3:25]>>[C:1]([C:5]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)[C:8]([OH:21])=[C:7]([CH2:22][NH:28][C:24]([CH3:27])([CH3:26])[CH3:25])[CH:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 86718740HCID 86718740, compound

Product 1

HCID 86718741HCID 86718741, compound

Procedure

5-(tert-Butyl)-3-((tert-butylamino)methyl)-3′-(trifluoromethyl)-[1,1′-biphenyl]-2-ol was prepared as a white solid using the procedure described in Example 27, Step 2 5-(tert-butyl)-2-hydroxy-3′-(trifluoromethyl)-[1,1′-biphenyl]-3-carbaldehyde and tert-butylamine. HPLC/MS Rt=6.64 min, m/z 380.2 (M+H+).

Sources & evidence

ORD record: ord-659751b61c79425f825bfd3b53940553
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09296696B2

Reaction notes

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