Tert-Butylamine → HCID 86718753, compound

HRID 929583Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[C:13]([CH2:15][CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=3)[CH:12]=[C:11]([CH:28]=O)[C:10]=2[OH:30])[CH:5]=[CH:6][C:7]=1[Cl:8].[C:31]([NH2:35])([CH3:34])([CH3:33])[CH3:32]>>[ClH:1].[C:31]([NH:35][CH2:28][C:11]1[CH:12]=[C:13]([CH2:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:25])([F:27])[F:26])=[CH:20][CH:19]=2)[CH:14]=[C:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[C:10]=1[OH:30])([CH3:34])([CH3:33])[CH3:32]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 86718755HCID 86718755, compound

Product 1

HCID 86718753HCID 86718753, compound

Procedure

3-((tert-Butylamino)methyl)-3′,4′-dichloro-5-(3-(4-(trifluoromethyl)phenyl)propyl)-[1,1′-biphenyl]-2-ol hydrochloride was prepared as a white solid using the procedure described in Example 9 from 3′,4′-dichloro-2-hydroxy-5-(3-(4-(trifluoromethyl)phenyl)propyl)-[1,1′-biphenyl]-3-carbaldehyde and tert-butylamine.

Sources & evidence

ORD record: ord-3a152fb58e054ad6874659ed15a7ccfb
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09296696B2

Reaction notes

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