Tert-Butylamine → HCID 86718762, compound

HRID 929586Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:24]=O)[C:12]([OH:23])=[C:13]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=2)[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:26]([NH2:30])([CH3:29])([CH3:28])[CH3:27]>>[ClH:21].[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=2)[C:12]([OH:23])=[C:11]([CH2:24][NH:30][C:26]([CH3:29])([CH3:28])[CH3:27])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 86718764HCID 86718764, compound

Product 1

HCID 86718762HCID 86718762, compound

Procedure

5-(Benzyloxy)-3-((tert-butylamino)methyl)-3′,4′-dichloro-[1,1′-biphenyl]-2-ol hydrochloride was prepared as a white solid using the procedure described in Example 9 from 5-(benzyloxy)-3′,4′-dichloro-2-hydroxy-[1,1′-biphenyl]-3-carbaldehyde and tert-butylamine.

Sources & evidence

ORD record: ord-4e7d8c28724d4770a2882982cfbe444d
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09296696B2

Reaction notes

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