HCID 11529459, compound → HCID 23525770, compound

HRID 929887Notes

Reaction equation

HRID 929887 reaction equation
[N+:1]([C:4]1[CH:21]=[CH:20][C:7]([O:8][CH:9]2[CH2:12][N:11]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:10]2)=[CH:6][CH:5]=1)([O-])=O>[Pd].O1CCCC1>[NH2:1][C:4]1[CH:21]=[CH:20][C:7]([O:8][CH:9]2[CH2:12][N:11]([C:13]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:14])[CH2:10]2)=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 11529459HCID 11529459, compound

Product 1

HCID 23525770HCID 23525770, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Tert-butyl 3-(4-nitrophenoxy)azetidine-1-carboxylate (1 g, 3.40 mmol) and tetrahydrofuran (20 ml) were added to 5% palladium on carbon (wet, 0.200 g, 1.879 mmol) in a 250 mL SS pressure bottle and the mixture was stirred for 1 hour at 30 psi and room temperature. The mixture was filtered through a nylon membrane and the fitrate was concentrated to give the title compound.

Workup

  1. filtrationThe mixture was filtered through a nylon membrane
  2. concentrationthe fitrate was concentrated

Sources & evidence

ORD record
ord-8a3f879a100c4fcf9aed9964fe75fdeb
Source dataset
uspto-grants-2016_03
Patent number
US09296723B2

Reaction notes

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