m-Chlorophenylhydrazine hydrochloride → HCID 89609975, compound

HRID 930039Notes

Reaction equation

HRID 930039 reaction equation
[Li].[Cl:2][C:3]1[CH:4]=[C:5]([C:10]([O-])=[CH:11][C:12](=O)[C:13]([O:15]CC)=[O:14])[CH:6]=[N:7][C:8]=1[F:9].ClC1C=C(C2N(C3C=CC=CN=3)N=C(C(O)=O)C=2)C=C(F)C=1.Cl.[Cl:43][C:44]1[CH:45]=[C:46]([NH:50][NH2:51])[CH:47]=[CH:48][CH:49]=1>>[Cl:43][C:44]1[CH:45]=[C:46]([N:50]2[C:10]([C:5]3[CH:6]=[N:7][C:8]([F:9])=[C:3]([Cl:2])[CH:4]=3)=[CH:11][C:12]([C:13]([OH:15])=[O:14])=[N:51]2)[CH:47]=[CH:48][CH:49]=1

Participants

4

Reactant 3

HCID 75331m-Chlorophenylhydrazine hydrochlorideHCID 89602575HCID 89602575, compoundHCID 131735140HCID 131735140, compound

Product 1

HCID 89609975HCID 89609975, compound

Procedure

240 mg (0.86 mmol) of the compound of Example 15A is reacted analogously to the synthesis of the compound of Example 20A with 230 mg (1.29 mmol) of 3-chlorophenylhydrazine hydrochloride. After hydrolysis, 21 mg (7% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-dbf2f42353a34e0dab2f6cbfbde0a58d
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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